Some loss here, some sadness there, some genetic vulnerability,
Some distortions in thinking, some diminished mood regulating ability,
Some ongoing stress that leads to, an increase in cortisol,
A deficiency of serotonin and nor-epinephrine, starts taking its toll.
As the days become months, the brain networks start going awry,
The limbic system comprising of amygdala, kicks-in in its full glory,
The PFC, both ventral and dorsal, gets subdued and becomes hypo-active,
You become lethargic and fatigued, and to the negative you are more attentive.
As the months become years, the brain structure is at stake,
The shortage of BDNF means, it can't new neurons make.
The hippocampus atrophies, neuro-genesis is held at bay,
Only with medication or therapy, can we reverse the damage, pray!
My brain may be depressed, my constitution weak, I'm down, but not out,
If you had to endure the things I lived, your brain too would have lost the bout.
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